Outbred strain Rat
CLEA Japan, Inc., Taconic Farms Inc. (USA), and Taconic Europe (Denmark) created the “Global Alliance for Laboratory Animal Standardization (GALASTM)” agreement in collaboration with the Central Institute for Experimental Animals to promote the international standardization of outbred stocks usable for safety testing in the field of toxicity and pharmacology. Based on these activities, this strain was developed for the purpose of steadily supplying high-quality laboratory animals worldwide through a production and supply system based on consistent criteria.
Wistar Hannover rats have been used for safety testing mainly in Europe. This strain is particularly suitable for long-term studies, i.e., 2-year carcinogenicity studies. Weight gain is relatively small even under unrestrained feeding, and the 2-year survival rate is more than 75% in both males and females.
Wistar Hannover GALAS rats are derived from the Han:WIST strain from the Zentral Institut fur Versuchstierzucht (ZfV) (Hannover, Germany). In 1989, 156 pairs were introduced from ZfV to the Institute for Biomedical Research (IBM) in Switzerland (IBM underwent a structural change [name change] to BRL Ltd. and RCC Ltd.). At and after the end of 1998, RCC Ltd. gave more than 50 pairs of pedigreed BrlHan:WIST rats to each GALAS member to use as seed rats for the Wistar Hannover GALAS strain.